Serology and Immunlogy

Modern Diagnostic Center Laboratory's Immunology/Serology division conducts diagnostic tests for a variety of infectious diseases and assesses the immune system.


What are serology and immunology?

In immunology, we study the functions and disorders of the immune system. The study of serum (the clear fluid separating after blood clots) is referred to as serology.

Our Modern Diagnostic Center Laboratory for immunology and serology concentrate on the following:

  • antigen recognition: These are proteins that a certain type of white blood cell produces in response to an antigen that the body encounters.

  • investigation of immune system issues: These include autoimmune illnesses, in which the immune system of the body destroys its own tissues, and immune system deficiencies (immunodeficiency disorders).

  • determining the suitability of organs, tissues, and fluids for transplantation



At Modern Diagnostic Center, we provide the following services in Serology and Immunology:

  • Identifying antibodies

  • Investigating problems with the immune system

  • Auto-immune disease detection

  • Transplant pathology and assays etc


At Modern Diagnostic Center

Detecting antibodies or antigens as indicators of infectious diseases is performed by the Modern Diagnostic Center Nepal’s Serology & Immunology Laboratory. A number of criteria must be met in order for an assay to be validated according to the International Standards Manual for Serological Assays published by the OIE. 

Our primary goal is to maintain high levels of quality control and ensure that all results are accurate and reproducible. Laboratory technicians interpret the test results to provide them with additional information beyond serological values.

Serology uses antibodies against cytomegaloviruses, herpes viruses, Epstein Barr Viruses, and toxoplasma to diagnose infectious illnesses. Analyzing plasma immunoglobulins (e.g., IgG, IgA, IgM, and IgE), complement proteins (e.g., C3, C4), and autoantibodies against cardiolipin, tissue transglutaminase, and double-stranded DNA are all examples of immune system measurements.

Furthermore, the Laboratory conducts a wide range of testing for particular IgE molecules, which cause allergies to hundreds of different chemicals.


Common Serology and Immunology Test




An antibody is a protein produced by the body that reacts with antigens. These proteins can be overproduced in many situations. These are some examples:

  • Infections

  • Autoimmune conditions

  • Cancers

  • Chronic illnesses

  • Allergies


Many situations can produce a deficiency of these proteins. Cancers, medications, and chronic disorders are examples of them.

Rheumatoid factor

Used to aid in the classification of arthritis and the diagnosis of rheumatoid arthritis. Other tests are often used to classify and identify kinds of arthritis.

Human leukocyte antigens (HLA) typing

Compatibility in organ, tissue, and bone marrow transplantation was tested. Paternity was also confirmed by testing. And to identify HLA-linked illnesses, such as certain autoimmune diseases.


More About Serology and Immunology

Antigens and antibodies are detected and measured in the immunology and serology department to assess whether an infectious illness, autoimmune condition, or other immunologic disease is present. This section collaborates closely with transfusion services, chemistry, microbiology, and molecular diagnostics.

Serum specimens are sent to the immunology and serology department in red-top, gold-top, and speckle-top tubes.

Tests in immunology and serology track how antigens and antibodies interact. Pathogens and red blood cells both have antigens as distinctive markers of their identities. A kind of white blood cell called a plasma cell produces antibodies to recognize and combat particular antigens that the immune system recognizes as foreign substances. 

The pathogen or red blood cell's antigen is bound by the antibody. Cellular components are brought to life by the antigen-antibody complex, aiding in the eradication and deactivation of invading pathogens.

Hepatitis, HIV, influenza, infectious mononucleosis, syphilis, and other viruses are a few of the more prevalent infectious disorders that may be found by immunology and serology testing.

Rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis (MS), celiac disease, and Crohn's disease are a few examples of common autoimmune disorders that are identified and tracked in the immunology and serology division.

The immunology and serology department may also perform specialized testing for determining compatibility for transplantation. Human Leukocyte Antigen (HLA) Typing is one example of specialized testing, which helps match organ donors and recipients.


Book the Date

Click here to schedule your Microlymphocytotoxicity (Serology) study for HLA B27.

For HLA typing panel ABC (Serology method ) and DR (molecular method): Click here to book the date

For Platelet Count-Immunological (CD41): Click here to book the date.